Isomorphous replacement

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Substitution isomorphe (Fr). Isomorpher Ersatz (Ge). Substitución isomorfa (Sp). изоморфное замещение (Ru). Metodo della sostituzione isomorfa (It). 同型置換法 (Ja).


A method of determining diffraction phases from the differences in intensity between corresponding reflections from two or more isomorphous crystals. Most commonly used in the determination of protein structures, where it is possible to derive isomorphous crystals of native protein and of heavy-atom derivatives.

See also

  • Section 2.3.3, International Tables of Crystallography, Volume B
  • International Tables of Crystallography, Volume F